1. Complete occlusion of the left common carotid artery by atheromatous plaque with thrombosis and calcification, involving 8 cm long cephalically from the point 1 cm from the aortic orifice. Arteriosclerosis of the right common carotid artery, severe, with ulceration and calcification, but without obstruction.

2. An old cystic anemic infarct of the right parieto-occipital lobe, facing the longitudinal fissure of the cerebrum, measuring 4 x 2 x 1 cm in dimension, in association with lacunae of the bilateral caudate nuclei and the left putamen. Externally fairly symmetric brain without distinct midline shift at sections (1,090 g). Histologically, a cystic cavity surrounded by loose glial tissue with minimal or no hemosiderin deposition or foam macrophage mobilization.

3. Moderate neuronal loss of the right Ammon's horn with degeneration and shrinkage of cell bodies, whereas almost unremarkable neuronal cells of the left Ammon's horn. Retraction of the cell body and pyknosis of the nuclei of the nerve cells of the cerebral cortex, diffuse and moderate. Unremarkable pigmented neuronal cells of the substantia nigra and locus ceruleus.

4. Mild pallor (secondary degeneration) of the right pyramis just above the level of the decussation of the caudal medulla.

5. Arteriosclerosis of the central nervous system;

a. cut ends of the bilateral internal carotid artery, with fibrous intimal thickening with calcium deposits and almost intact internal elastic lamina, with up-to-30% stenosis.

b. right middle cerebral artery, accompanying an unruptured saccular aneurysm (berry aneurysm) without intrasaccular thrombosis, located at the first branch point deep in the Sylvian fissure, measuring 4 x 4 mm in external dimension. The distal portion of the MCA showing hyalinous degeneration of the wall with luminal obstruction by fibrous tissue.

c. left middle cerebral artery, with up-to-20% stenosis.

d. bilateral vertebral and basilar arteries, mild, with up-to-20% stenosis.

1. Diabetic nephropathy; mildly nodular surface of the kidneys (150; 140 g) with arteriosclerotic scars and rather patent lumen of the renal hilar arteries. Histologically, diffuse increase in mesangial matrix of the glomeruli (diffuse lesions), Kimmelstiel-Wilson nodules (nodular lesions) surrounded by capillaries, and exudative lesions with a hyaline cap. Arteriosclerosis of arcuate and interlobular arteries, marked, with fibrously thickened intima embedding cholesterol crystals.

2. Langerhans' islets of the pancreas apparently remaining intact by HE-stain, with very rare hyalinous degeneration.

3. Atherosclerosis of the whole length of the aorta, severe, with ulceration and calcification, only sparing the cardiac base, accompanying a fusiform aneurysmal dilatation of the lower abdominal aorta, measuring 7 x 6 cm.

4. Concentric hypertrophy of the left ventricle of the heart with mild dilatation (580 g), macroscopically and microscopically without prominent ischemic fibrotic scar. Coronary arteriosclerosis with scattered atheromas, moderate, with up-to-70% stenosis. Histologically, very localized myocardial coagulative necrosis of the papillary muscles of the posterolateral aspect of the left ventricle.

5. Multiple small infarcts of the spleen (150 g), measuring up to 3.0 x 1.5 cm in size. Arteriosclerosis of the pancreaticosplenic artery, marked. Histologically, coagulative necrosis with occluded artery containing cholesterol crystals. 

1. Congestion of the liver (1,420 g), moderate. Histologically, mild and focal fatty metamorphosis.

2. Anthracosis of the fairly well-aerated lungs (weight; ND), mild, with yellow clear pleural effusion (50; 280 ml), without adhesion.

3. Mixed bone marrow of the upper third of the femur, the lumbar vertebrae and the sternum.

4. Interstitial fibrosis of the thyroid (18 g), with ectopic thyroid tissue in a regional lymph node.

5. Cyst of the pars intermedia of the pituitary gland, measuring 6 x 5 mm in dimension.

6. Unremarkable adrenals (9.8; 6.5 g).

7. Well-nourished female cadaver (155 cm/ 49 kg). Status post CAVH.